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Surface plasmon resonance sensor chips

Surface plasmon resonance (SPR) sensor chips are high quality glass chips coated with a thin gold layer through vacuum deposition. These chips are functionalized with chemical groups for biomolecular (protein, antibody, enzyme, polypeptide, DNA, etc.) immobilization. The sizes of these chips are currently available for Biacore, Reichert Technologies, Bionavis, BiosensingUSA, Biosuplar and most home-made SPR instruments. All chips are packaged in inert gas. These chips are stand along and are not mounted on plastic substrate at this time (please send us a message for mounted chips). Please click here for how to replace the chip on the original mounting plastics. All biochips are manufactured on a per order basis. Each package contains three pieces of chips. All listed prices are for per package and in USD.

Bare gold SPR chips, non-functionalized gold coated plate

DescriptionCatalog NoSizePackPriceQty
Bare gold SPR chip1000004-320x12x0.55mm3 pcs$75

Carboxylate functionalized SPR chips carry negative charge in buffer with pH greater than 4. They covalently bind to biomolecules with primary amine groups after EDC/NHS activation. This binding is more efficient than aldehide-amine binging. Polyethylene glycol (PEG) is monofunctional polymer that is well known for resisting non-specific adsorption. Polysaccharides (dextran and arginic acid) have long and bulky chains. Synthetic polymers (SP) have long and slim chains. SP type I is highly negatively charged polymer due to high density of carboxylate. SP type II is mildly negatively charged polymer. SP type III has long spacer arms that extend the carboxylate groups away from the main chains.

DescriptionCatalog NoSizePackPriceQty
Carboxylated PEG SPR chip, basic 1121114-320x12x0.55mm3 pcs$120
Carboxylated PEG SPR chip, stablized1391124-320x12x0.55mm3 pcs$210
Carboxylated dextran SPR chip, thin 1511124-320x12x0.55mm3 pcs$180
Carboxylated dextran SPR chip, thick 1511134-320x12x0.55mm3 pcs$210
Arginic acid SPR chip, thin 1561124-320x12x0.55mm3 pcs$180
Carboxylated Synthetic polymer I SPR chip, thin 1311124-320x12x0.55mm3 pcs$180
Carboxylated Synthetic polymer I SPR chip, thick 1311134-320x12x0.55mm3 pcs$210
Carboxylated Synthetic polymer II SPR chip, thin 1321124-320x12x0.55mm3 pcs$180
Carboxylated Synthetic polymer II SPR chip, thick1321134-320x12x0.55mm3 pcs$210
Carboxylated Synthetic polymer III SPR chip, thin1331124-320x12x0.55mm3 pcs$180
Carboxylated Synthetic polymer III SPR chip, thick1331134-320x12x0.55mm3 pcs$210

Amine functionalized SPR chips carry positive charge in buffer with pH less than 10. They covalently bind to biomolecules with EDC/NHS activated carboxyl groups.

DescriptionCatalog NoSizePackPriceQty
Amine functionalized polymer SPR chip, thin 1344124-320x12x0.55mm3 pcs$180
Amine functionalized polymer SPR chip, thick1344134-320x12x0.55mm3 pcs$210
Chitosan SPR chip, thin1544124-320x12x0.55mm3 pcs$180

Epoxide functionalized SPR chips covalently bind to thiol,amine, hydroxyl, and other nucleophilic groups. The reaction with hydroxyl groups requires high pH and takes more than 12 hours.

DescriptionCatalog NoSizePackPriceQty
Epoxide functionalized polymer SPR chip, thin1511424-320x12x0.55mm3 pcs$180
Epoxide functionalized polymer SPR chip, thick1511434-320x12x0.55mm3 pcs$210

Maleimide functionalized SPR chips covalently bind to thiol groups (-SH). This reaction is very specific and fast.

DescriptionCatalog NoSizePackPriceQty
Maleimide functionalized polymer SPR chip, thin 1516424-320x12x0.55mm3 pcs$240
Maleimide functionalized polymer SPR chip, thick1516434-320x12x0.55mm3 pcs$270

Disulfide functionalized SPR chips covalently bind to thiol groups (-SH) through thio-disulfide exchange. After binding, the new formed disulfide bond can be broken by another thiol compound.

DescriptionCatalog NoSizePackPriceQty
Disulfide functionalized polymer SPR chip, thin 1512624-320x12x0.55mm3 pcs$240
Disulfide functionalized polymer SPR chip, thick1512634-320x12x0.55mm3 pcs$270

Ni complexed SPR chips bind to his-tagged proteins.

DescriptionCatalog NoSizePackPriceQty
Ni chelated SPR chip, thin 1513524-320x12x0.55mm3 pcs$270
Ni chelated SPR chip, thick1513534-320x12x0.55mm3 pcs$300

UV-initiator modified SPR chips covalently bind to all biomolecules under ultraviolet illumination. The reaction does not rely on any chemical groups on the biomolecules. It takes about 15 minutes under 100W UV lamp.

DescriptionCatalog NoSizePackPriceQty
UV initiator I modified SPR chip, thin 1517524-320x12x0.55mm3 pcs$210
UV initiator I modified SPR chip, thick1517534-320x12x0.55mm3 pcs$240

Protein A immobilized SPR chips bind to immunoglobulins, especially IgG.

DescriptionCatalog NoSizePackPriceQty
Protein A immobilized SPR chip, thin 1770124-320x12x0.55mm3 pcs$270
Protein A immobilized SPR chip, thick1770134-320x12x0.55mm3 pcs$300

Streptavidin immobilized SPR chips bind to biotin-labeled biomolecules.

DescriptionCatalog NoSizePackPriceQty
Streptavidin immobilized SPR chip, thin 1770524-320x12x0.55mm3 pcs$270
Streptavidin immobilized SPR chip, thick1770534-320x12x0.55mm3 pcs$300


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